Drugs & Supplements

Amoxicillin allergy

Are you concerned that you or your loved one has an Amoxicillin allergy? Amoxicillin is a penicillin antibiotic used to treat bacterial infections, including bronchitis, pneumonia, pharyngitis, anthrax, Lyme disease, dental abscess, and infections of ear, nose, throats, skin, and urinary tract. Though it can be highly effective in treating bacterial infections, it also comes with a list of potential side effects.

What sorts of side effects and allergy symptoms should you look out for?  What’s and amoxicillin rash? Here what you need to know about amoxicillin allergy.

Amoxicillin side effects

The side effects of amoxicillin are listed below:

  • Diarrhoea
  • Stomach upset
  • Headache
  • Vagina yeast infection
  • Hyperactivity
  • Agitation
  • Insomnia
  • Dizziness
  • Maculopapular rash
  • Exfoliative dermatitis
  • Urticaria
  • Hypersensitivity vasculitis
  • Nausea and vomiting
  • Anaemia
  • Thrombocytopenia
  • Leucopenia
  • Agranulocytosis
  • Potentially fatal: neuromuscular hypersensitivity; pseudomembranous colitis

If you are experiencing any of the above symptoms after taking amoxicillin, you likely do not have amoxicillin allergy. Speak up to your doctor to double-check, but it likely nothing major to be concerned about.

Amoxicillin allergy symptoms

If you don’t have an allergic reaction to amoxicillin, you may experience the following symptoms:

  • Rash
  • Itching
  • Hives
  • Shortness of breath
  • Swelling of lips, face, or tongue

Mild symptoms typically clear up on their own., but speak to the doctor if they do not. If you experience shortness of breath or swelling of lips, face, or tongue, you must seek immediate medical attention, as this could be life-threatening reactions.

Amoxicillin rash

While most antibiotics of risk of causing a rash, amoxicillin is more likely than other antibiotics to cause a rash. Skin rashes when taking amoxicillin can be common especially in children. Sometimes it’s hard to tell that if the rash is because of allergy or not. There are two types of rashes that can be caused by amoxicillin:

Hives are raised, itchy

Maculopapular rash

What to do after being diagnosed with amoxicillin allergy?

True allergy can become worse over time, so if you experience an allergic reaction to amoxicillin, you should let you, doctor, to know about it. Tell your doctor if you experienced side effects to amoxicillin as well. Together, you can decide on a paper solution to your amoxicillin allergy or sensitivity to amoxicillin.

 Mechanism of action of Amoxicillin

Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.


  • Renal and hepatic disease
  • Pregnancy
  • Lactation
  • Infectious mononucleosis
  • Lactation
  • Excreted in breast milk
  • Use caution hypersensitivity

Amoxicillin interaction

May reduce the efficacy of OC. May increase the effect of anticoagulants. Increases risk of allergic reactions w/ allopurinol. Increases and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin.


If you have Amoxicillin allergy, the best prevention is to avoid the drug. The steps that you can take to prevent amoxicillin allergy are:

Inform health care worker: be sure that your amoxicillin allergy or other antibiotics allergy is clearly identified in your medical records. Inform other health care providers, such as a dentist or other medical professions.

Wear a bracelet: wear a medical alert bracelet that identifies your drugs allergies. This information can ensure the proper treatment in case of an emergency.

Carry emergy epinephrine: if your allergy caused anaphylaxis or other severe reactions, your doctor will likely to prescribe a self-injecting syringe and needle device ( epinephrine auto-injector )


Amoxicillin allergy is an abnormal reaction of your immune system to antibiotics drug called amoxicillin. It is prescribed as treating various bacterial infections like pharyngitis, acute otitis media and many more. Common amoxicillin allergy is discussed above.

Therefore, an appropriate diagnosis is needed when amoxicillin allergy is suspected to ensure the best treatment option in the future. Other antibiotics, particularly those with chemical properties similar to amoxicillin, also can result in allergy reactions.


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